Regulation of hippocampal neurogenesis in adulthood

Although these studies emphasize an important role of diet on mental health, further work is necessary to establish the mechanisms underlying these behavioural effects.Interestingly, the hippocampus is one of the two structures in the adult brain where the formation of newborn neurons, or neurogenesis, persists.Adult neurogenesis in the hippocampal subgranular zone (SGZ) is involved in learning and memory throughout life but declines with aging.

Treating wild type but not CD44-null NSCs with HA inhibits NSC proliferation.AHN varies among different genetic backgrounds in mice and a correlation between the level of hippocampal neurogenesis and the performance in hippocampal-dependent learning tasks is observed between mice of different strains.Environment also has a major impact on AHN (this will be discussed in detail later) and changes in neurogenesis induced by the environment correlates with performance in hippocampal-dependent learning tasks.Growth factors, cytokines, neurotransmitters and hormones are the types of extrinsic factors that have been found to play a role in regulating AHN and have been reviewed by Mu Moreover, AHN is also subject to intrinsic epigenetic regulation such as DNA methylation, histone acetylation and non-coding RNAs.These intrinsic factors controlling AHN have been recently reviewed by Sun As described above, adult-born hippocampal neurons are functional and integrated into the hippocampal circuitry.

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